[Script Info] Title: [Events] Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text Dialogue: 0,0:00:00.01,0:00:00.97,Default,,0000,0000,0000,,[ Background Music ] Dialogue: 0,0:00:00.97,0:00:01.86,Default,,0000,0000,0000,,>> Welcome back. Dialogue: 0,0:00:01.86,0:00:04.04,Default,,0000,0000,0000,,We are bringing you some\Nof the most compelling Dialogue: 0,0:00:04.04,0:00:05.41,Default,,0000,0000,0000,,"Mysteries of the Mind" tonight. Dialogue: 0,0:00:05.41,0:00:07.61,Default,,0000,0000,0000,,And this one strikes\Nduring adolescence Dialogue: 0,0:00:08.13,0:00:10.73,Default,,0000,0000,0000,,and makes otherwise\Nnormal teenagers collapse. Dialogue: 0,0:00:11.17,0:00:15.04,Default,,0000,0000,0000,,Not just into a deep sleep, but\Ninto a mysterious netherworld, Dialogue: 0,0:00:15.26,0:00:18.36,Default,,0000,0000,0000,,a world filled with\Nhallucination, paralysis, Dialogue: 0,0:00:18.36,0:00:21.63,Default,,0000,0000,0000,,and strange sensations that\Nstrike without warning, Dialogue: 0,0:00:22.14,0:00:25.73,Default,,0000,0000,0000,,linger without a cure,\Nand can last a lifetime. Dialogue: 0,0:00:26.52,0:00:37.52,Default,,0000,0000,0000,,[ Music ] Dialogue: 0,0:00:38.02,0:00:38.08,Default,,0000,0000,0000,,[ Background Music ] Dialogue: 0,0:00:38.08,0:00:40.58,Default,,0000,0000,0000,,>> An insatiable need for sleep. Dialogue: 0,0:00:40.58,0:00:50.69,Default,,0000,0000,0000,,Sudden episodes of paralysis,\Nvivid hallucinations, Dialogue: 0,0:00:50.69,0:00:53.71,Default,,0000,0000,0000,,this is the life\Nof a narcoleptic. Dialogue: 0,0:00:53.71,0:00:56.17,Default,,0000,0000,0000,,>> I don't really even\Nremember a whole lot Dialogue: 0,0:00:56.17,0:00:57.96,Default,,0000,0000,0000,,of my sophomore year\Njust because I slept Dialogue: 0,0:00:57.96,0:00:59.74,Default,,0000,0000,0000,,so much through my classes. Dialogue: 0,0:00:59.96,0:01:02.47,Default,,0000,0000,0000,,>> Anthony Raymond was\Nyour normal high school kid Dialogue: 0,0:01:02.47,0:01:06.51,Default,,0000,0000,0000,,who loved acting and the theater\Nthen his life mysteriously Dialogue: 0,0:01:06.51,0:01:07.93,Default,,0000,0000,0000,,started to change. Dialogue: 0,0:01:08.04,0:01:10.49,Default,,0000,0000,0000,,>> I just started feeling\Nsleepy throughout the day. Dialogue: 0,0:01:10.55,0:01:11.73,Default,,0000,0000,0000,,I didn't think much of it. Dialogue: 0,0:01:12.18,0:01:15.93,Default,,0000,0000,0000,,I just thought it was\Nsome weird puberty thing. Dialogue: 0,0:01:15.93,0:01:17.81,Default,,0000,0000,0000,,[ Background Noise ] Dialogue: 0,0:01:17.81,0:01:22.23,Default,,0000,0000,0000,,>> Occasional daily naps turned\Ninto a constant need for sleep Dialogue: 0,0:01:22.31,0:01:23.90,Default,,0000,0000,0000,,that he could never satisfy. Dialogue: 0,0:01:24.47,0:01:26.77,Default,,0000,0000,0000,,>> I was sleeping every\Nchance I could get. Dialogue: 0,0:01:26.100,0:01:31.55,Default,,0000,0000,0000,,In addition, I started\Nexperiencing these other weird Dialogue: 0,0:01:31.55,0:01:33.53,Default,,0000,0000,0000,,symptoms like sleep\Nparalysis at night. Dialogue: 0,0:01:33.74,0:01:34.93,Default,,0000,0000,0000,,>> And what is it exactly? Dialogue: 0,0:01:35.40,0:01:38.27,Default,,0000,0000,0000,,>> I'll be lying down, and all Dialogue: 0,0:01:38.27,0:01:40.82,Default,,0000,0000,0000,,of a sudden I can't move\Nany part of my body. Dialogue: 0,0:01:41.43,0:01:47.41,Default,,0000,0000,0000,,And usually what will accompany\Nthis are these hallucinations, Dialogue: 0,0:01:47.41,0:01:50.20,Default,,0000,0000,0000,,which not only do I see\Nthings and hear things, Dialogue: 0,0:01:50.69,0:01:51.96,Default,,0000,0000,0000,,but I also feel things. Dialogue: 0,0:01:52.63,0:01:56.87,Default,,0000,0000,0000,,I can remember one time\Nbeing completely paralyzed Dialogue: 0,0:01:56.87,0:02:01.70,Default,,0000,0000,0000,,and feeling a fox kind\Nof crawl under my back. Dialogue: 0,0:02:02.02,0:02:03.85,Default,,0000,0000,0000,,>> Can you scream when you\Nare paralyzed like that? Dialogue: 0,0:02:03.85,0:02:04.56,Default,,0000,0000,0000,,>> No. I can't scream. Dialogue: 0,0:02:04.56,0:02:05.85,Default,,0000,0000,0000,,>> You can't move\Nyour body at all? Dialogue: 0,0:02:05.85,0:02:07.96,Default,,0000,0000,0000,,>> But eventually\NI break out of it Dialogue: 0,0:02:07.96,0:02:10.82,Default,,0000,0000,0000,,and I will scream or something. Dialogue: 0,0:02:10.82,0:02:11.06,Default,,0000,0000,0000,,[ Inaudible Remark ] Dialogue: 0,0:02:11.06,0:02:11.30,Default,,0000,0000,0000,,[ Background Talking ] Dialogue: 0,0:02:11.30,0:02:16.60,Default,,0000,0000,0000,,>> And then there's\Nthe most difficult Dialogue: 0,0:02:16.60,0:02:18.63,Default,,0000,0000,0000,,and potentially dangerous\Nsymptom Dialogue: 0,0:02:18.63,0:02:20.95,Default,,0000,0000,0000,,of narcolepsy, cataplexy. Dialogue: 0,0:02:21.19,0:02:24.12,Default,,0000,0000,0000,,At any given moment\NAnthony would collapse. Dialogue: 0,0:02:24.24,0:02:27.05,Default,,0000,0000,0000,,He would be paralyzed\Nfor minutes at a time. Dialogue: 0,0:02:27.77,0:02:30.53,Default,,0000,0000,0000,,>> Probably the scariest\Nthing is falling to the ground Dialogue: 0,0:02:30.98,0:02:33.36,Default,,0000,0000,0000,,and not being totally sure\Nthat you are going to fall Dialogue: 0,0:02:33.36,0:02:34.66,Default,,0000,0000,0000,,in a position where\Nyou can breathe. Dialogue: 0,0:02:34.98,0:02:38.71,Default,,0000,0000,0000,,I could fall in a space where\Nmy face might be smothered Dialogue: 0,0:02:38.71,0:02:42.11,Default,,0000,0000,0000,,by a cushion or something. Dialogue: 0,0:02:42.28,0:02:45.97,Default,,0000,0000,0000,,>> In extreme cases,\Nlike this Scottish girl, Dialogue: 0,0:02:45.97,0:02:50.19,Default,,0000,0000,0000,,it can happen more than 45\Ntimes a day, usually brought Dialogue: 0,0:02:50.19,0:02:54.29,Default,,0000,0000,0000,,on by emotional excitement like\Nlaughing, anger or surprise. Dialogue: 0,0:02:54.90,0:02:56.94,Default,,0000,0000,0000,,Experts estimate\Nthat at least half Dialogue: 0,0:02:57.11,0:02:59.35,Default,,0000,0000,0000,,of narcoleptics have cataplexy. Dialogue: 0,0:03:01.36,0:03:05.02,Default,,0000,0000,0000,,For Anthony, these sometimes\Ndaily episodes make driving, Dialogue: 0,0:03:05.26,0:03:08.03,Default,,0000,0000,0000,,working, and dating\Nnearly impossible. Dialogue: 0,0:03:08.54,0:03:11.16,Default,,0000,0000,0000,,>> It starts in the\Nneck and the tongue, Dialogue: 0,0:03:11.92,0:03:13.22,Default,,0000,0000,0000,,unable to move those parts. Dialogue: 0,0:03:13.22,0:03:15.12,Default,,0000,0000,0000,,And then it goes to the\Nlegs and then eventually, Dialogue: 0,0:03:15.85,0:03:17.53,Default,,0000,0000,0000,,you can't move anything. Dialogue: 0,0:03:18.09,0:03:22.29,Default,,0000,0000,0000,,>> And there's nothing you can\Ndo to pull yourself out of it? Dialogue: 0,0:03:22.29,0:03:23.75,Default,,0000,0000,0000,,>> Nothing I can do except wait. Dialogue: 0,0:03:23.100,0:03:28.58,Default,,0000,0000,0000,,I can try really hard to\Nmove and every now and then, Dialogue: 0,0:03:28.92,0:03:32.29,Default,,0000,0000,0000,,I'll gain just enough\Nstrength that I might be able Dialogue: 0,0:03:32.29,0:03:34.18,Default,,0000,0000,0000,,to jerk my arm up or something. Dialogue: 0,0:03:34.18,0:03:37.29,Default,,0000,0000,0000,,>> And are you consciously\Nthinking I'm going to ride this Dialogue: 0,0:03:37.29,0:03:38.10,Default,,0000,0000,0000,,out for another minute? Dialogue: 0,0:03:38.52,0:03:41.28,Default,,0000,0000,0000,,>> Yeah. It's just kinda\Nlike that bad dream Dialogue: 0,0:03:41.28,0:03:44.58,Default,,0000,0000,0000,,where you can't move\Nand you can't scream. Dialogue: 0,0:03:44.81,0:03:47.17,Default,,0000,0000,0000,,>> Anthony's was\Nreally a classical case Dialogue: 0,0:03:47.37,0:03:48.64,Default,,0000,0000,0000,,when he came to me. Dialogue: 0,0:03:48.70,0:03:50.16,Default,,0000,0000,0000,,This is a perfect slide here. Dialogue: 0,0:03:50.16,0:03:50.26,Default,,0000,0000,0000,,[ Background Talking ] Dialogue: 0,0:03:50.26,0:03:52.98,Default,,0000,0000,0000,,>> Dr. Emmanuel Mignot\Nis Anthony's doctor Dialogue: 0,0:03:53.13,0:03:55.35,Default,,0000,0000,0000,,and the director of\NCenter for Narcolepsy Dialogue: 0,0:03:55.35,0:03:56.70,Default,,0000,0000,0000,,at Stanford University. Dialogue: 0,0:03:57.09,0:03:59.96,Default,,0000,0000,0000,,He says that despite all\Nthe sleep Anthony gets, Dialogue: 0,0:04:00.19,0:04:01.96,Default,,0000,0000,0000,,he's never well rested. Dialogue: 0,0:04:02.09,0:04:03.76,Default,,0000,0000,0000,,>> They are exhausted\Nall the time. Dialogue: 0,0:04:03.76,0:04:05.36,Default,,0000,0000,0000,,They take little naps,\Nthey feel better. Dialogue: 0,0:04:05.83,0:04:09.25,Default,,0000,0000,0000,,But then after one hour or two\Nhours, it just starts again. Dialogue: 0,0:04:09.77,0:04:13.46,Default,,0000,0000,0000,,And at night the same thing,\Njust exhausted and they arrive Dialogue: 0,0:04:13.46,0:04:15.92,Default,,0000,0000,0000,,in their bed, boom,\Nthey sleep and then Dialogue: 0,0:04:15.92,0:04:18.34,Default,,0000,0000,0000,,after two hours they wake\Nup unable to fall asleep. Dialogue: 0,0:04:18.48,0:04:21.07,Default,,0000,0000,0000,,Basically the cause of\Nnarcolepsy is very simple. Dialogue: 0,0:04:21.07,0:04:21.13,Default,,0000,0000,0000,,[ Background Talking ] Dialogue: 0,0:04:21.13,0:04:21.20,Default,,0000,0000,0000,,[ Background Music ] Dialogue: 0,0:04:21.20,0:04:24.71,Default,,0000,0000,0000,,>> Narcoleptics can't\Nproduce a brain chemical Dialogue: 0,0:04:24.71,0:04:26.62,Default,,0000,0000,0000,,called Hypocretin. Dialogue: 0,0:04:26.62,0:04:28.57,Default,,0000,0000,0000,,Normally it helps\Nyou stay awake. Dialogue: 0,0:04:28.94,0:04:32.29,Default,,0000,0000,0000,,Without it narcoleptics\Nconstantly fall it REM Dialogue: 0,0:04:32.29,0:04:35.20,Default,,0000,0000,0000,,or dream sleep, but\Nthey do not fall Dialogue: 0,0:04:35.20,0:04:38.62,Default,,0000,0000,0000,,into the deep restorative\Nstages of sleep so they wake Dialogue: 0,0:04:38.62,0:04:41.29,Default,,0000,0000,0000,,up too soon, and wake up tired. Dialogue: 0,0:04:41.29,0:04:44.55,Default,,0000,0000,0000,,The mystery, what\Ncauses the death Dialogue: 0,0:04:44.55,0:04:46.24,Default,,0000,0000,0000,,of these precious brain cells? Dialogue: 0,0:04:46.24,0:04:50.37,Default,,0000,0000,0000,,And why does it often\Nhappen during adolescence? Dialogue: 0,0:04:50.37,0:04:52.70,Default,,0000,0000,0000,,The other mystery,\Nhow to restore Dialogue: 0,0:04:52.70,0:04:56.85,Default,,0000,0000,0000,,or replace those cells\Nand cure narcolepsy? Dialogue: 0,0:04:56.85,0:04:59.32,Default,,0000,0000,0000,,Fortunately, doctors\Nhave developed drugs Dialogue: 0,0:04:59.32,0:05:02.53,Default,,0000,0000,0000,,to treat the symptoms. Dialogue: 0,0:05:02.53,0:05:05.91,Default,,0000,0000,0000,,>> It's kind of gross,\Nbut it does the trick. Dialogue: 0,0:05:07.01,0:05:10.18,Default,,0000,0000,0000,,>> Every day and every night,\NAnthony takes a carefully- Dialogue: 0,0:05:10.18,0:05:11.60,Default,,0000,0000,0000,,prescribed mix of drugs. Dialogue: 0,0:05:11.83,0:05:16.60,Default,,0000,0000,0000,,>> I have got about 20\Nminutes and I'll be asleep. Dialogue: 0,0:05:16.76,0:05:19.18,Default,,0000,0000,0000,,>> One drug gets\NAnthony's brain and body Dialogue: 0,0:05:19.18,0:05:22.44,Default,,0000,0000,0000,,into a deep restorative\Nsleep, so he's well rested. Dialogue: 0,0:05:23.06,0:05:26.83,Default,,0000,0000,0000,,It also helps reduce cataplexy,\Nbut it doesn't work for long. Dialogue: 0,0:05:27.11,0:05:29.85,Default,,0000,0000,0000,,Anthony needs a second dose\Nin the middle of the night. Dialogue: 0,0:05:30.29,0:05:35.58,Default,,0000,0000,0000,,>> It is 2:11 a.m.\Nand I am awake again. Dialogue: 0,0:05:36.01,0:05:38.18,Default,,0000,0000,0000,,>> Anthony also needs a\Nstimulant during the day Dialogue: 0,0:05:38.18,0:05:41.96,Default,,0000,0000,0000,,and antidepressants to ease\Nhis constant sleepiness Dialogue: 0,0:05:42.18,0:05:43.09,Default,,0000,0000,0000,,and cataplexy. Dialogue: 0,0:05:43.46,0:05:46.57,Default,,0000,0000,0000,,>> OK, it's now 7:30 in\Nthe morning and I just-- Dialogue: 0,0:05:46.57,0:05:46.63,Default,,0000,0000,0000,,[ Background Talking ] Dialogue: 0,0:05:46.63,0:05:47.100,Default,,0000,0000,0000,,>> But even with\Nall those drugs, Dialogue: 0,0:05:47.100,0:05:51.08,Default,,0000,0000,0000,,Anthony can only stay\Nawake for about six hours Dialogue: 0,0:05:51.08,0:05:52.34,Default,,0000,0000,0000,,at a time during the day Dialogue: 0,0:05:52.64,0:05:59.08,Default,,0000,0000,0000,,so he must follow a\Nstrict daily nap schedule. Dialogue: 0,0:05:59.08,0:05:59.16,Default,,0000,0000,0000,,[ Background Music ] Dialogue: 0,0:05:59.16,0:06:00.48,Default,,0000,0000,0000,,>> The first is in mid-morning, Dialogue: 0,0:06:00.86,0:06:02.64,Default,,0000,0000,0000,,usually in his first\Nor second class. Dialogue: 0,0:06:03.26,0:06:06.41,Default,,0000,0000,0000,,Anthony closes his eyes\Nfor 15 to 20 minutes. Dialogue: 0,0:06:06.48,0:06:08.81,Default,,0000,0000,0000,,>> If he's sleeping, he's\Ngoing to miss something Dialogue: 0,0:06:09.22,0:06:11.92,Default,,0000,0000,0000,,but I think he more than\Ncompensates for that. Dialogue: 0,0:06:13.07,0:06:16.18,Default,,0000,0000,0000,,>> He also has to take a nap the\Nminute he gets home from school. Dialogue: 0,0:06:17.42,0:06:19.11,Default,,0000,0000,0000,,>> If I postpone\Na nap long enough, Dialogue: 0,0:06:19.39,0:06:20.88,Default,,0000,0000,0000,,I just can't really function. Dialogue: 0,0:06:21.24,0:06:23.33,Default,,0000,0000,0000,,>> But no matter what\Nmedication he takes, Dialogue: 0,0:06:23.33,0:06:27.45,Default,,0000,0000,0000,,or how many naps he has, Anthony\Nstill has occasional bouts Dialogue: 0,0:06:27.67,0:06:30.51,Default,,0000,0000,0000,,of cataplexy. Dialogue: 0,0:06:30.51,0:06:31.09,Default,,0000,0000,0000,,[ Inaudible Remark ] Dialogue: 0,0:06:31.09,0:06:31.67,Default,,0000,0000,0000,,[ Background Talking ] Dialogue: 0,0:06:31.67,0:06:33.49,Default,,0000,0000,0000,,>> See his bobbing head here? Dialogue: 0,0:06:33.100,0:06:37.57,Default,,0000,0000,0000,,This one happened while\Nhe was watching a comedy. Dialogue: 0,0:06:38.61,0:06:40.38,Default,,0000,0000,0000,,But despite all these\Nchallenges, Dialogue: 0,0:06:40.38,0:06:43.06,Default,,0000,0000,0000,,Anthony still has big\Nplans for the future. Dialogue: 0,0:06:43.61,0:06:47.33,Default,,0000,0000,0000,,He starts college in September\Nand hopes to become a teacher. Dialogue: 0,0:06:47.92,0:06:50.99,Default,,0000,0000,0000,,With no cure on the\Nhorizon, Anthony is ready Dialogue: 0,0:06:50.99,0:06:53.67,Default,,0000,0000,0000,,for a life he knows\Nwill be a nonstop, Dialogue: 0,0:06:53.75,0:06:56.59,Default,,0000,0000,0000,,24-hour game of beat the clock. Dialogue: 0,0:06:56.59,0:06:58.86,Default,,0000,0000,0000,,>> I can live the rest\Nof my life like this. Dialogue: 0,0:06:59.16,0:07:02.95,Default,,0000,0000,0000,,Narcolepsy is a problem,\Nbut it's not the worst thing Dialogue: 0,0:07:02.95,0:07:05.15,Default,,0000,0000,0000,,in the world for me\Nthat could happen. Dialogue: 0,0:07:05.15,0:07:07.84,Default,,0000,0000,0000,,And I'm still living. Dialogue: 0,0:07:07.84,0:07:09.94,Default,,0000,0000,0000,,>> And you know you\Ncan handle it. Dialogue: 0,0:07:10.42,0:07:10.60,Default,,0000,0000,0000,,>> Yeah. Dialogue: 0,0:07:12.70,0:07:15.92,Default,,0000,0000,0000,,>> And Anthony is doing a whole\Nlot more than just handling it. Dialogue: 0,0:07:16.08,0:07:17.36,Default,,0000,0000,0000,,He happens to be thriving. Dialogue: 0,0:07:17.44,0:07:19.46,Default,,0000,0000,0000,,He is far from alone\Nthough when it comes Dialogue: 0,0:07:19.46,0:07:21.02,Default,,0000,0000,0000,,to struggling with narcolepsy. Dialogue: 0,0:07:21.51,0:07:25.33,Default,,0000,0000,0000,,The disorder effects\Nabout 135,000 Americans. Dialogue: 0,0:07:25.33,0:07:27.82,Default,,0000,0000,0000,,Now in most cases,\Nsymptoms first appear Dialogue: 0,0:07:27.82,0:07:30.73,Default,,0000,0000,0000,,between the ages of 10 and 25. Dialogue: 0,0:07:31.34,0:07:32.29,Default,,0000,0000,0000,,We're gonna take a short break. Dialogue: 0,0:07:32.40,0:07:33.84,Default,,0000,0000,0000,,We'll be right back.